Principal Research Associate, Process Development (T-Cell Therapy)

Salary $85,000 to $110,000 base salary
LocationLos Angeles
Employment type Permanent
Discipline
Life Sciences

Job description

Principal Research Associate, Process Development
Santa Monica, CA

Our client is a global, clinical-stage biotechnology company using tumor mutation profiles to engineer individualized T cell therapies.

Position Summary
The Principal Research Associate, Process Development is responsible for supporting and contributing to the design and execution of studies to develop and further optimize clinical manufacturing processes of this biotech's portfolio of engineered TCR T cell therapies. This role is based in Santa Monica, CA, and reports to the Senior Scientist, Process Development.  

Essential Functions and Responsibilities 

  • Participate in the design, execution and support of laboratory studies for development, optimization, and manufacture of genome engineered TCR T cell products using non-viral genome editing tools. 

  • Execute and support analytical methods for process development studies. 

  • Support experimental designs, planning, execution, analysis, and reporting results of process development studies. 

  • Participate in a cross-functional team to transfer technology to cGMP manufacturing partners. 

  • Support, author, and review protocols, technical reports, regulatory documents and memos to summarize experiments and investigations. 

  • Collaborate with internal and external partners to evaluate and implement new process technologies to develop next generation processes. 

  • Collaborate within the project team to interpret study results and contribute to technical discussions for subsequent study design. 

  • Work effectively in a team environment to meet project timeline and objectives. 

  • Perform other duties as assigned. 

Supervisory Responsibilities

  • Oversee Junior associates in execution of development activities.   

Required Skills/Abilities

  • Proficiency with Microsoft Excel or statistical analysis software (JMP, Minitab, Prism, etc.) for analyzing and presenting data. 

  • Working understanding of US/EU regulatory requirements and working knowledge of cGMPs. 

  • Ability to think critically, analytically and have demonstrated troubleshooting and problem-solving skills based on deductive reasoning. 

  • Ability to design and execute experiments with minimal technical supervision. 

Education and Experience 

  • MS degree in Immunology, Cell Biology, Molecular biology, Bioengineering with 2+ years relevant experience or similar BS degree with 4+ years relevant experience within the pharmaceutical or biotech industries.  

  • At least 3 years of relevant experience in developing production processes for genome engineered primary cells (required) including T cells (highly preferred).? 

  • A minimum of two (2) years practical experience with Flow Cytometry.  

  • Hands-on experience performing analytical methods typically used in the manufacture and characterization of biological products. 

The anticipated salary range for candidates who will work in Santa Monica, CA is $85,000 to $110,000. The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job type and length of experience within the industry, education, etc.